Author  
Place of duty  
Title   비호지킨 림프종에 대한 COP - BLAM 복합화학요법의 치료효과 ( COP - BLAM Combination Chemotherapy for the Treatment of Intermediate and High Grade Non - Hodgkin's Lymphoma )
Publicationinfo   1994 Jan; 026(05): 806-815.
Key_word   Non-Hodgkin's lymphoma, Chemotherapy, COP-BLAM regimen
Full-Text  
Abstract   Between March 1987 and December 1993, 45 patients with intermediate and high grade non- Hodgkin's lymphoma were treated with a COP-BLAM(cyclophosphamide, oncovin, prednisone, procarbazine, bleomycin, adriamycin) combination chemotherapy. The median age was 49 years(range 16-76). 29 patiets were male and 16 patients were female. The common histologic types were diffuse large cell type(68.9%), diffuse small cleaved cell type(13.3%), and diffuse mixed small and large cell type(11.1%). The proportion of patients with 'B symptom, bulky mass, and LDH>550 IU/L at diagnosis was 42.4%, 6.7%, 33.3%, respectively. The rate of complete remission was 71.1%, and overall response rate was 93.3%. 2 year survi- val rate was 76.8/, but the median survival time was not reached right now(the median follow up time: l7 months). Age, serum LDH level at diagnosis, lower performance scale, stage, and cell type were significantly associated with CR rate. Stage, serum LDH level at diagnosis, and bulky mass were significantly associated with 2 year survival rate. Overall toxicity was acceptible without any treatment related deaths.
저 자   이재성(Jae Seong Lee),서장수(Jang Su Suh),현명수(Myung Soo Hyun)